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Conditions pertaining to hormonal imbalances such as gynecomastia and testicular size reduction may also be caused by AAS.

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The word anabolic, referring to anabolism, comes from the Greek ἀναβολή anabole, "that which is thrown up, mound." They are one of three types of sex hormone agonists, the others being estrogens like estradiol and progestogens like progesterone.

AAS were synthesized in the 1930s, and are now used therapeutically in medicine to stimulate muscle growth and appetite, induce male puberty and treat chronic wasting conditions, such as cancer and .

Their use is referred to as doping and banned by most major sporting bodies.